INTRODUCTION TO CLINICAL PATHOLOGY

Academic Year 2025/2026 - Teacher: STEFANIA STELLA

Expected Learning Outcomes

The course develops skills in the Clinical Pathology aiming to teach the student to apply, evaluate and interpret the laboratory tests used to study of the main diseases of the blood, alterations of the coagulative-fibrinolytic system, changes in liver and kidney function, some endocrinopathies, oncological and cardiovascular diseases. The student will be able to learn the biomarkers used in clinical pathology.

1. Knowledge and understanding: at the end of the course, students will acquire the knowledge of the main laboratory tests to the study the blood diseases, the coagulative-fibrinolytic system and liver and kidney function alterations.

2. Ability to apply knowledge and understanding: once the knowledge of the main laboratory tests has been acquired, the students will be able to evaluate and interpret the aforementioned tests.

3. Making judgments: through the executions, the students will be able, independently, to apply, evaluate, and interpret different laboratory tests.

4. Communication skills: the student will acquire the necessary communication skills within the main laboratory tests.

5. Learning skills: the course aims to provide the student with the basic knowledge to autonomously interpret the main laboratory tests.

Course Structure

The lessons are held in the classroom with the help of PDF presentations made available to students. The presentations do not replace the reference texts, but serve as educational support for the program carried out. Should teaching be carried out in mixed mode or remotely, it may be necessary to introduce changes with respect to previous statements, in line with the program planned and outlined in the syllabus.

Required Prerequisites

Knowledge of biochemistry, cell biology, anatomy and physiology.

Attendance of Lessons

Attendance of lessons is mandatory.

Detailed Course Content

The course is organized into theoretical lessons combined with exercises aimed to interpreter the results of different types of laboratory and molecular test.

Program:

- RT - PCR

- Real Time PCR

- Digital PCR

- Liquid biopsy

- Detections of gene mutations by Sanger sequencing and NGS sequencing in the main blood diseases

- Tumoral biomarkers

- Heredofamilial syndromes and Lynch syndromes

Textbook Information

1. Federici G. Medicina di Laboratorio. Mc Graw-Hill Companies

2.Ciaccio M., Lippi G Biochimica Clinica e Medicina di Laboratorio, EdiSES

3. Flyers in PDF

Course Planning

	Subjects	Text References
1	RT - PCR
2	Real Time PCR
3	Digital PCR
4	Liquid Biopsy
5	Detections of gene mutations by Sanger sequencing and NGS sequencing in the main blood diseases
6	Tumoral Biomarkers	Testo 1: capitolo 15; Testo 2: capitolo 28, 29
7	Heredofamilial syndromes and Lynch syndromes

Learning Assessment

Learning Assessment Procedures

Oral examination.

Verification of learning can also be carried out electronically, should the conditions require it.

Examples of frequently asked questions and / or exercises

Nucleic acid extraction methods

VERSIONE IN ITALIANO

Degree Course in

Biology